- Product Name 3-BROMO-5-NITROTOLUENE
- cas 52488-28-5
- purity 99%
Others
Factory Export Top Purity 3-BROMO-5-NITROTOLUENE 52488-28-5 In Stock
- Molecular Formula: C7H6BrNO2
- Molecular Weight: 216.034
- Vapor Pressure: 0.012mmHg at 25°C
- Melting Point: 68-72 °C
- Refractive Index: 1.592
- Boiling Point: 269.5 °C at 760 mmHg
- Flash Point: 120 °C
- PSA： 45.82000
- Density: 1.615 g/cm3
- LogP: 3.18890
3-BROMO-5-NITROTOLUENE(Cas 52488-28-5) Usage
|
General Description |
3-Bromo-5-nitrotoluene is a chemical compound that belongs to the category of nitroaromatic compounds. It is a pale yellow solid with a molecular formula of C7H6BrNO2 and a molecular weight of 216.03 g/mol. 3-BROMO-5-NITROTOLUENE is used as a building block in the synthesis of various pharmaceuticals, dyes, and other organic compounds. It is also commonly used as an intermediate in the manufacture of agrochemicals and rubber chemicals. Additionally, 3-Bromo-5-nitrotoluene has been found to have antimicrobial activity, making it potentially useful in the development of novel antimicrobial agents. However, it is important to handle this compound with care, as it is toxic and may cause irritation to the skin, eyes, and respiratory system. |
InChI:InChI=1/C7H6BrNO2/c1-5-2-6(8)4-7(3-5)9(10)11/h2-4H,1H3
52488-28-5 Relevant articles
Ipso Nitration of Aryl Boronic Acids Using Fuming Nitric Acid
Baucom, Kyle D.,Brown, Derek B.,Caille, Seb,Murray, James I.,Quasdorf, Kyle,Silva Elipe, Maria V.
supporting information, (2021/06/30)
The ipso nitration of aryl boronic acid ...
Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents
Shao, Hao,Foley, David W.,Huang, Shiliang,Abbas, Abdullahi Y.,Lam, Frankie,Gershkovich, Pavel,Bradshaw, Tracey D.,Pepper, Chris,Fischer, Peter M.,Wang, Shudong
supporting information, (2021/02/16)
Cyclin-dependent kinases (CDKs) are a fa...
Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group
Fu, Zhengjiang,Jiang, Yongqing,Wang, Shuiliang,Song, Yuanyuan,Guo, Shengmei,Cai, Hu
supporting information, p. 3003 - 3007 (2019/05/10)
A highly regioselective Pd-catalyzed car...
meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C?H Borylation
Li, Xuejing,Deng, Xingwang,Coyne, Anthony G.,Srinivasan, Rajavel
supporting information, p. 8018 - 8023 (2019/05/29)
Herein, we report the meta-nitration of ...
52488-28-5 Process route
-
-
827-24-7
2-bromo-4-methyl-6-nitroaniline
-
-
52488-28-5
1-bromo-3-methyl-5-nitrobenzene
Conditions
| Conditions | Yield |
|---|---|
|
With
sulfuric acid; sodium nitrite;
In
ethanol;
at 73 - 78 ℃;
|
66%
|
|
2-bromo-4-methyl-6-nitroaniline;
With
hydrogenchloride; sodium nitrite;
In
water; acetic acid;
at 5 - 10 ℃;
for 2h;
With
hypophosphorous acid;
In
water; acetic acid;
at 0 - 20 ℃;
for 48h;
|
64%
|
|
With
ethanol; cis-nitrous acid;
|
|
|
With
sulfuric acid; sodium nitrite;
Erwaermen der erhaltenen Diazoniumsalz-Loesung mit Kupfer-Pulver;
|
|
|
With
hypophosphorous acid;
Yield given. Multistep reaction;
1) diazotization;
|
|
|
With
sulfuric acid; sodium nitrite;
In
ethanol;
|
|
|
With
copper(I) oxide; sulfuric acid; hypophosphorous acid; sodium nitrite;
Yield given. Multistep reaction;
1.) H2O, -2 deg C - -3 deg C, 2 h, 2.) H2O, -5 deg C, 90 min; 0 deg C, 10 min;
|
|
|
With
sulfuric acid; N,N-dimethyl-formamide; sodium nitrite;
Yield given. Multistep reaction;
1.) water, 2.) water;
|
|
|
bei der Entamidierung;
|
|
|
Multi-step reaction
with
2
steps
1: aqueous HCl / Diazotization.
Kochen der Diazoniumsalz-Loesung mit KI
2: copper-powder / 230 °C
With
hydrogenchloride; copper;
|
|
|
With
sulfuric acid; sodium nitrite;
In
ethanol;
at 73 - 78 ℃;
for 0.916667h;
|
-
-
849062-36-8
(3-bromo-5-methylphenyl)boronic acid
-
-
52488-28-5
1-bromo-3-methyl-5-nitrobenzene
Conditions
| Conditions | Yield |
|---|---|
|
With
nitric acid;
In
1,2-dichloro-ethane;
at 70 ℃;
for 16h;
Inert atmosphere;
|
99%
|
52488-28-5 Upstream products
-
500728-37-0
1-bromo-2-iodo-5-methyl-3-nitrobenzene
-
827-24-7
2-bromo-4-methyl-6-nitroaniline
-
102170-56-9
2-bromo-6-methyl-4-nitroaniline
-
77811-44-0
4-bromo-2-methyl-6-nitroaniline
52488-28-5 Downstream products
-
124289-22-1
5-methyl-3-nitrobenzonitrile
-
1071718-57-4
N ,N '-bis-(3-bromo-5-methyl-phenyl)-hydrazine
-
97378-75-1
bis-(3-bromo-5-methyl-phenyl)-diazene
-
113882-33-0
5-Methyl-3-nitrobenzoic acid
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